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S-Adenosyl Methionine Full Potency Highest Concentrationof Active S, S Form Promotes: Longevity* Joint Strength* Liver Detoxification* Mood and Brain Function Jarrow FORMULAS&reg pharmaceutical grade, stabilized SAM-e 200provides a full 200 mg SAM-e (net yield) from 400 mg of SAM-e tosylatedisulfate. SAM-e 200 is manufactured under low temperature and lowhumidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S, S FormFound in all living cells, SAM-e is a metabolite of methionine (an essentialamino acid). SAM-e is a chiral molecule and consists of two forms: (S, S)SAM-e and (R, S) SAM-e. The biologically active form is the (S, S) structure, while the (R, S) structure is biologically inactive. Jarrow FORMULAS®SAM-e is made naturally by microbiological fermentation and then speciallyprocessed without solvents to preserve 68-80% (S, S) SAM-e, the highestactive level available.SAM-e has been clinically shown to have the following benefits: Joint StrengthSAM-e supports the production of healthy connective tissue through transulfuration.In this process, critical components of connective tissue, including glucosamineand the chondroitin sulfates, are sulfated by SAM-e metabolites.* Brain MetabolismSAM-e methylation reactions are involved in the synthesis of neurotransmitterssuch as L-DOPA, dopamine and related hormones, serotonin, epinephrine andphosphatidylcholine (a component of lecithin).* LongevityMethylation of DNA appears to be important in the suppression of errors inDNA replication. Demethylation of DNA is considered a contributor to the agingprocess.* Proper methylation through substances such as SAM-e positivelyinfluences longevity.* LiverSAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function.*