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Autoimmune Diseases: Acute and Complex Situations provides a detailed overview of conditions associated with autoimmune diseases that are considered either life-threatening or requiring complex management. These include abdominal pain, arthritis, cutaneous ulcers, gastrointestinal hemorrhage, epilepsy, pancreatitis, stroke and white-matter CNS lesions.   Autoimmune Diseases: Acute and Complex Situations addresses the latest clinical and immunological prognostic factors that may help to identify patients at higher risk of developing potentially life-threatening involvement. This book comprehensively helps the reader to diagnose these patients, in whom an early therapeutic approach is essential.   Autoimmune Diseases: Acute and Complex Situations is a valuable reference tool for rheumatologists, internists, immunologists, and all the specialists involved in the multidisciplinary care of patient with rheumatic and systemic autoimmune diseases.

First Prize, Orthopaedics and Rheumatology, BMA Awards 2009 This state-of-the-art reference provides current insights into the etiology, diagnosis and management of rheumatoid arthritis. Leading international authorities in RA examine all of the latest scientific and clinical developments in understanding and managing this challenging disease, including new concepts in pathogenesis, epidemiology, risk factors, imaging, clinical outcomes and treatment. It's the guidance you need to offer optimal care to your patients with rheumatoid arthritis. Presents the work of leading international experts in rheumatoid arthritis for guidance you can trust. Provides the very latest understanding of the pathogenesis of rheumatoid arthritis, including molecular pathways/mechanisms, and genetic and environmental factors that instigate and drive the disease.Includes comprehensive coverage of clinical features of rheumatoid arthritis including articular, peri-articular and extra-articular manifestations, comorbidities, and outcome measures-disease activity, joint assessment, imaging, and more-for expert diagnosis and monitoring of disease progression.Examines evidence-based treatment options-including traditional and biologic DMARDs and combination therapies-as well as promising therapies on the horizon, placing up-to-date guidance on disease modifying or disease controlling agents at your fingertips.

Microbiologists, medical mycologists, immunologists, and biochemists are increasingly working together to focus on the processes involved in the progression and treatment of fungal disease.  Host-Fungus Interactions: Methods and Protocols is designed for research scientists who are involved in this work and interested in undertaking new or comparative studies of interactions between the mammalian host and clinically important fungal pathogens. Aiming to combine approaches for reverse genetics in pathogenic fungi with methods for their application in in vitro and in vivo models of disease, the book includes methods for the culture and genetic manipulation of the primary fungal pathogens and the opportunistic pathogens, as well as methods for investigating host-fungus interactions in model systems.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.   Comprehensive and practical, Host-Fungus Interactions: Methods and Protocols describes available molecular methods and fungal infection models in great detail in order to encourage researchers to try new approaches to investigating host-fungus interactions with added levels of confidence.

PEPTAMEN JUNIOR® WITH PREBIO¹™ Complete Elemental Liquid Diet for Children provides a specifically designed protein, lipid, vitamin and mineral profile for children ages 1 to 10 with impaired gastrointestinal function. Designed to be well tolerated by your most challenging pediatric patients, PEPTAMEN JUNIOR WITH PREBIO¹ features the prebiotic fiber blend PREBIO¹™, which helps support a healthy gut microflora. It also features Proven Blend™ consisting of whey-based peptides, a unique antioxidant system and an optimal lipid blend. PEPTAMEN JUNIOR WITH PREBIO¹ is useful for the dietary management of children with chronic diarrhea/malabsorption, growth failure, short-bowel syndrome, bowel transplants, cerebral palsy, Crohn's disease, HIV/AIDS and cystic fibrosis. PEPTAMEN JUNIOR WITH PREBIO¹ provides complete or supplemental nutrition support and may also be used as a dual feeding with TPN or as a transition diet from TPN.

Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened up a completely new line of research in an effort to establish a function for GHB.Gamma-Hydroxybutyrate: Pharmacological and Functional Aspects has brought together the combined expertise of many of the leading authorities on the biochemistry, physiology and pharmacology of GHB in the central nervous system. Each chapter is an in-depth review of the field and the book itself will appeal to all neurobiologists interested in neurotransmitter mechanisms, as well as to clinicians and other health-care workers interested in this fascinating chemical.

Gruve is an unprecedented, personalized, scientifically proven solution that enables healthy, sustainable weight loss. wear your gruve all day and learn how to increase your daily activity, burn more calories and reach your personal health goals. sync your gruve with gruve online to view your calorie burn and activity intensity. log into gruve online and notice that your daily burn goal has been set based on a number of personal factors, not some generic formula like other programs. losing weight is as simple as reaching your get to greentm goal each day. included with your 1 year gruve subscription is the 12 week gruve guide which provides you with the education, motivation and support you need to make long term, sustainable behavior changes that lead to better health and weight management. testimonials "i knew i needed to do something to lose weight and be more active. gruve taught me just how much time i spent sitting and how to be more active throughout my workday, it was the small changes that made a big difference for me. the gruve motivated me to be more active." "the gruve program is great. it is a great accountability partner and it is definitely holding me to a standard that i would not have set for myself lately." "using the gruve has been an eye opening experience, i was amazed how accurate it was. i found that wearing gruve has helped to significantly lowered my blood pressure and lowered my cholesterol. gruve gave me the extra push that i needed to i changed my life." "i've only had gruve a week and already it is a can't-do-without-it item - and my children love to check and see what color my halo bar is at - certainly motivating to "get to the green" so i'm not running up and down the stairs at bedtime at the behest of my children to "make it turn green, mommy!". you have a great product."

Perspectives in Nutrition, 8th edition, is an introductory nutrition text appropriate for nutrition and science majors, as well as mixed majors/non-majors nutrition courses. This text has the richly deserved reputation of providing an accurate, current, in-depth and thoughtful introduction to the dynamic field of nutrition. The 8th edition introduces a new author team whose primary goal has been to maintain the strengths and philosophy that have been the hallmark of this book yet enhance the accessibility and personal application of materials for today's students.

This second volume of the Atlas of Electroencephalography is devoted to the vast subject of epilepsies, covering them according to modern classification criteria: focal epilepsies, generalised epilepsies, epileptic encephalopathies, specific situations and etiologies, and reflex seizures. As in Volume 1, each electroencephalogram shown is analysed to highlight the most significant features that may be useful for diagnosis and interpretation. Emphasis is placed on the most common types of epilepsy because of the practical nature of the book, but some less well known and more confusing forms are also shown. The book provides a summary of current views on the main categories of epilepsy and doctors who carry out EEGs will find it a valuable aid to interpretation. It is also aimed at all doctors who have to deal with epileptic patients, as well as technicians working in neurophysiology laboratories.

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embyro. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. It provides comprehensive information on hCG from basic science to clinical medicine Written by specialists in the field

Authored by 40 of the most prominent and renowned international scientists from academia, industry, institutions and government, this handbook explores mature, evolving technologies for a clean, economically viable alternative to non-renewable energy. In so doing, it includes how hydrogen can be safely produced, stored, transported and utilized, while also covering such broader topics as the environmental impact, education and regulatory developments.

A hypoallergenic formula proven to manage colic fast, often within 48 hours. If your baby has an allergy to the cow's milk protein in infant formula, Nutramigen with enflora LGG contains both extensively hydrolyzed protein to manage colic fast and enflora LGG to promote immune system balance. These two ingredients offer a more comprehensive approach working together to help babies feel better faster. The benefits of these two ingredients include. Hypoallergenic, easy-to-digest protein, proven to promote skin health in infants through 18 months of age. Proven to promote digestive system health within 1 week of use. Effectively manages colic in 48 hours, enflora LGG probiotic to promote immune system balance. Nutramigen with enflora LGG is also. Nutritionally balanced, lactose free, and has no added sucrose.

The conditions of Crohn’s disease and ulcerative colitis are excellent examples of  how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient’s quality of life. It has led to the development of unique novel immunomodulatory treatments. These are continuously being refined to treat not only the two original conditions in the gut, but the systemic immunologic illness with its associated extraintestinal disorders. New therapies are sometimes complex and associated with important risks requiring a deeper understanding of their molecular principles from clinicians.   Crohn’s Disease and Ulcerative Colitis serves as a unique combined resource for physicians and scientists addressing the needs of both groups. It will stimulate exchange and collaboration and shorten the path between discovery and application of new knowledge and also help clinicians understand new therapeutic concepts from their origins. This volume provides an introduction to mucosal immunology which forms the basis of modern immunotherapy. It also serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy as well as conventional and complex immunomodulatory principles. Each chapter is written by experts in their field and includes the most up to date information. Crohn’s Disease and Ulcerative Colitis will be of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis and related autoimmune disorders.

Now in its 10th Edition, this best-selling anatomy and physiology book is better than ever! Body Structures & Functions has been completely updated and now includes great new features such as a review of medical terminology, case studies to promote critical thinking, and complete coverage on the effects of aging. A new chapter on Infection Control has been added to give more coverage to this critical topic in health care.

Mimicking nature – from science fiction to engineering reality Humans have always looked to nature’s inventions as a source of inspiration. The observation of flying birds and insects leads to innovations in aeronautics. Collision avoidance sensors mimic the whiskers of rodents. Optimization algorithms are based on survival of the fittest, the seed-picking process of pigeons, or the behavior of ant colonies. In recent years these efforts have become more intensive, with researchers seeking rules, concepts, and principles of biology to inspire new possibilities in materials, mechanisms, algorithms, and fabrication processes. A review of the current state of the art, Biomimetics: Nature Based Innovation documents key biological solutions that provide a model for innovations in engineering and science. Leading experts address a wide range of topics, including: Artificial senses and organs Mimicry at the cell–materials interface Multiscale modeling of plant cell wall architecture and tissue mechanics The making of biomimetic composites Electroactive polymer (EAP) actuators as artificial muscles EAP-based refreshable braille displays Biomimetic optics from the angles of biology and plants Biomimicry of flying birds, insects, and marine biology Applications of biomimetics in manufacturing, products, and medicine Robotics, including the development of human-like robots Biologically inspired design as a tool for interdisciplinary education The biomimetic process in artistic creation The final chapter outlines the challenges to biomimetic-related innovation and offers a vision for the future. A follow-up to Biomimetics: Biologically Inspired Technologies (2005), this comprehensive reference methodically surveys the latest advances in this rapidly emerging field. It features an abundance of illustrations, including a 32-page full-color insert, and provides extensive references for engineers and scientists interested in delving deeper into the study of biomimetics.

Studies of mammary gland biology are critically important given the prevalence of breast cancer in the population. There are many other reasons to study this organ, however. It represents an excellent model system for research into developmental mechanisms, gene regulation, tissue organization, hormonal action, secretion, and stem cell biology, revealing general principles that can be extended to other organs and tissues. Moreover, many in vitro, ex vivo, and in vivo techniques have been developed using the mammary gland model and may be applied to other systems. This book therefore provides valuable lessons for all cell, developmental, and cancer biologists.

Revolutionary and original, this treatise presents a new paradigm of "emergence" and "complexity", with applications drawn from numerous disciplines, including artificial life, biology, chemistry, computation, physics, image processing, information science, etc. CNN is an acronym for Cellular Neural Networks when used in the context of brain science, or Cellular Nonlinear Networks, when used in the context of emergence and complexity. A CNN is modeled by cells and interactions: cells are defined as dynamical systems and interactions are defined via coupling laws. The CNN paradigm is a universal "Turing machine" and includes cellular automata and lattice dynamical systems as special cases. While CNN paradigm is an example of "reductionism" par excellence, the true origin of emergence and complexity is traced to a much deeper new concept called local activity. The numerous complex phenomena unified under this mathematically precise principle include self organization, dissipative structures, synergetic, order from disorder, far-from-thermodynamic equilibrium, collective behaviours, edge of chaos, etc. Written with a high level of exposition, this completely self-contained monograph is ill with over 200 colour illustrations of emergent phenomena.

In spite of the apparent simplicity of silica’s composition and structure, scientists are still investigating fundamental questions regarding the formation, constitution, and behavior of colloidal silica systems. Colloidal Silica: Fundamentals and Applications introduces new information on colloid science related to silica chemistry as well as theoretical and experimental aspects of significant areas of colloidal silica science and technology. This resource is dedicated to helping researchers find new uses of silica and answers to practical problems as its industrial use continues to grow steadily in traditional and novel areas. Written by leading silica scientists around the world, this book reflects developments in the field since silica scientist Ralph K. Iler published his authoritative book on silica chemistry in 1979. It discusses properties and methods of characterization, synthesis, and preparation of silica in terms of industrial applications. Following an analysis of the surface chemistry of various silicas, the book explores methods for measuring particle size and useful characterization techniques for determining structure, stability, and reactivity. The authors then focus on various studies, analytical methods, and current applications involving silica gels and powders, silica coatings, colloidal silica, and sol-gel technology. Colloidal Silica: Fundamentals and Applications features up-to-date material relating to fields as diverse as catalysis, metallurgy, electronics, glass, ceramics, paper and pulp technology, optics, elastomers, food, health care, and industrial chromatography. It is ideal for scientists interested in silica chemistry and physics as well as those not familiar with the subject.

PEPTAMEN® 1.5 Complete High-Calorie Elemental Diet is ready to use for complete or supplemental tube feeding. It is specifically formulated for easy digestion and absorption for patients with impaired gastrointestinal function and normal or increased caloric requirements. Patients who could benefit from PEPTAMEN 1.5 include those with malabsorption that is complicated by fluid restriction, elevated caloric requirements, volume sensitivity, shortened feeding cycle or aggressive goal-rate attainment. PEPTAMEN 1.5 may also be useful as a nocturnal feeding, as a dual feeding with TPN or as a transition diet from TPN. PEPTAMEN 1.5 is available in the ULTRAPAK® Enteral Closed System, a prefilled closed system to reduce set-up time, minimize the potential for bacterial contamination, decrease waste and provide the flexibility of a hang time of up to 48 hours.

Shilajit in Perspective is a modern multi-disciplinary approach to a well known but highly debated rejuvenator (rasayana) of traditional Hindu ayurvedic medicine. Ghosal and coworkers have relentlessly investigated the chemistry and bioactivities of shilajit since the early seventies. Detailed research shows that shilajit contains two unique compounds viz. DCPs (dibenzo- pyrone chromopproteins) and their key nuclear components DBPs (dibenzo- pyrones). Shilajit is a paleohumus with marine invertebrate fossils being the major contributors. These are important to maintain the health status of man. The importance of DCPs/DBPs in energy synthesis (ATP) has been highlighted along with the claim that it is a potent immunomodulator and antioxidant. A carefully researched book containing a large spectrum of modern scientific methods of isolation, purification and standardization of a strongly potent organo-mineral drug which is a must read for all researchers and scientists in the field of natural products.

For most of our history, humans lived in small hunter-gatherer groups whose diets, living conditions, and environmental pressures were very different from what most humans face today. The result is that the evolutionary adaptations which proved beneficial in our past may prove less so now. This fascinating book explores the implications of human evolutionary history for human health and medicine. The topics include the evolution of antibiotic resistance, the evolution of pathogen virulence, the evolution of aging, the design of vaccines, and population- and genotype-specific reactions to drugs and susceptibility to disease. The book also discusses new insights into mother-offspring conflict during pregnancy, menstruation, menopause, child abuse, homicide, depression, schizophrenia, and many chronic degenerative diseases, such as cancer and osteoporosis. Written by leading experts in evolutionary medicine and addressed to medical students and researchers and evolutionary biologists, the book describes the state of the art and provides clear access to the primary literature. It also provides compelling arguments for why the tools evolutionary biology belong in every doctor's tool-kit.

This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management. The status of the rapidly evolving field of disease-modifying drugs is presented, with emphasis on the most promising therapies currently being tested. Experts discuss disease and symptom management for MS subtypes, including neuromyelitis optica and pediatric MS. In addition, key scientific advances in MS pathology, genetics, immunology and epidemiology are presented. The fourth edition has been extensively revised, featuring more than 50% new material. All chapters have been substantially updated to provide current information on rapidly evolving topics and this volume contains 15 new chapters, reflecting the growth of the field in recent years. This book is an essential reference for practitioners caring for MS patients, investigators planning or conducting clinical trials, and clinical trial sponsors.